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Comparatively more sustained release was seen from the formulations F2 & F3 at pH 6.8 and pH 7.4 after 7 h of drug release profiling.
Furthermore, theragnostic efficacies of N Chitosan-DMNPs were confirmed in the in vivo model by determining their therapeutic dosing schedule based on drug release profiling and in vivo MRI study.
The therapeutic dosing of N Chitosan-DMNPs were determined because these were maximally delivered within 1 h at the tumor sites and then over 80% of drug was released in the in the acidic environments within the tumor for 24 h, as judged from in vivo MRI and drug release profiling studies.
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Figure 7 In vitro drug release profiles.
A good sustained release profile is achieved.
Figure 8 Release profiles of 3,4-D.
The release profile then tended to plateau.
The system usually provides nonlinear release profile.
The release profiles are shown in Fig. 7.
In vitro drug release profile was investigated for different formulations.
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