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However, a significant release of matrix molecules into the culture medium was also noticeable.
One potential mechanism responsible for the observed increase in mechanical compliance is the release of matrix metalloproteinase-I (MMP-I).
Grote K, Flach I, Luchtefeld M, Akin E, Holland SM, Drexler H et al. Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P H oxidase-derived reactive oxygen species.
The expression of 5-LO by activated macrophages in symptomatic plaques leads to leukotriene B4 (LTB4) accumulation and enhanced synthesis and release of matrix metalloproteinases (MMPs) that can promote plaque rupture.
The host-mediated inflammatory response to periodontal pathogens and their components, release of matrix metalloproteinases, alteration in lipoprotein metabolism and poor dietary habits may contribute to the atheroma pathogenesis in patients with periodontal disease.
The injection of mtDNA can activate neutrophils and increase the release of matrix metalloproteinase-8 (MMP-8), a pro-inflammatory cytokine, leading to severe inflammation in mouse lungs.
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While the accuracy of the standard two-steps routine ((i) crushing, (ii) melting) may be affected by possible crushing-induced release of matrix-sited 3Hec, this new isochron technique does not involve the preliminary crushing step.
Cathepsin B is a major cysteine protease involved in the degradation of extracellular matrix proteins, as well as in the activation of precursor forms of other proteases and in release of matrix-bound growth factors.
In addition, IL-1 contributes to the development of vascular damage by stimulating cell proliferation and differentiation and the release of matrix-degrading enzymes.
Addition of AMD3100 blocked the binding of SDF-1 with CXCR4, removing the stimulatory trigger for the release of matrix-degrading enzymes, such as MMPs.
Therefore, if cartilage degeneration in OA leads to a release of matrix-derived danger signals, they might be recognized by the TLRs of the close-by chondrocytes.
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