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The chemical's release has been shown, in humans, to facilitate feelings of trust and well-being, and in female prairie voles, a monogamous species of rodent, to connect the act of sex to the formation of faithful attachments.
Additionally, BDNF release has been shown to be induced by CGRP [9].
In the mammalian retina, excess glutamate release has been shown to be involved in retinal ganglion cell (RGC) death associated with various diseases.
This activity-dependent differential transmitter release has been shown to rely on a mechanistic shift in the mode of exocytosis through the regulated dilation of the secretory fusion pore between granule and cell surface membranes.
Glutamate release has been shown to occur following an increase of cytosolic calcium in astrocytes [36].
The calcium-induced protease release has been shown to be one of the major inducers of necrosis [25], [26].
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Systemic inflammation and cytokine release have been shown to induce muscle injury and increase the incidence of ICUAW detected in the ICU [7, 51 53].
Bile acids may also affect incretin release, having been shown to induce secretion of glucagon-like peptide-1 (GLP-1) through activation of the G-protein-coupled receptor TGR5 [ 44, 45].
Furthermore, loss of dop-3 activity in C. elegans has recently been shown to increase acetylcholine release, whereas null alleles of genes required for acetylcholine release have been shown to rescue the SWIP phenotype in dat-1 (ok157 ) animals (Allen et al. 2011).
In addition, simvastatin induced long-lasting fura-2 calcium transients in human skeletal muscle that led to activation of calpain and caspaces 3 and 9. Calcium chelation and ryanodine, via inhibition of calcium-induced calcium release, have been shown to abrogate these effects.
Both quetiapine extended-release and quetiapine immediate-release have been shown to produce similar high levels of sedation intensity 4 14 hours postdose in a randomized, double-blind study involving inpatients with bipolar depression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com