The juror was due to retire from her job in the fall, but her husband said she called her boss after she was released from sequestration and retired over the telephone.
Subsequently, NFκB is released from sequestration in the cytoplasm, permitting translocation of NFκB dimers into the nucleus where they activate the transcription of target genes [2], [3], [4], [5], [6], [7].
Beyond this point, PP2A-B55 is rapidly released from sequestration; half is available to act on other substrates within 74 s.
Cdc14 is released from sequestration in the nucleolus at meiosis I exit due to the activity of the FEAR network, however the MEN functions only in meiosis II (Buonomo et al. 2003; Marston et al. 2003; Kamieniecki et al. 2005; Attner and Amon 2012).
For example p53 is stabilized by releasing it from sequestration by MDM2 while p73-dependant transcription is abrogated (perhaps by tighter binding to MDM2) during events such as mitosis [ 67].
It has been described that isothiocynates cause release of Nrf2 from sequestration by Keap1, and its subsequent translocation into the nucleus.
When released from p100 sequestration, p52 RelB, p50 RelB, and, as recently shown, p50 RelA dimers shuttle to the nucleus to activate transcription of specific target genes [5] [8].
The effect of H19 knockdown (i.e., downregulation of Igf1r) would be abrogated in the presence of iLet7, which acts to neutralize let-7 released from H19 sequestration.
The curves show the fraction of Endos that remains phosphorylated (purple) and the fraction of PP2A-B55 that is released from pEndos sequestration (orange) as a function of time t in sec.
