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Importantly, the release competence of the granules was not affected by palmitate.
We emphasize that insulin secretion from palmitate-treated β cells is not inhibited as a consequence of reduced release competence.
It should be emphasized that the amplifying effect requires elevation of [Ca2+]i but that glucose somehow increases the release competence of the secretory granules and their likelihood of undergoing exocytosis in response to a given increase in [Ca2+]i.
This observation raises the interesting possibility that biphasic glucose-induced insulin results from the time-dependent changes in electrical activity and [Ca2+]i following a step elevation of glucose [62] rather than the sequential release of distinct functional pools of secretory granules that differ with regard to release competence and/or proximity to the release sites [17].
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In 1960, Chouard hypothesized that there might be a connection between vernalization (facilitation of floral competence) and release from endodormancy.
Entrapment and drug release studies showed the competence of hybrid nanoparticles with respect to the a) zinc loading capacity, b) congruence with zinc physicochemical attributes, and c) release profile of their zinc load.
Wild-type muscle fibres lose both evoked and spontaneous miniature end-plate potentials (mEPPs) during overnight incubation, whereas WldS prevents this loss and preserves excitability and competence to release the neurotransmitter.
Docking is considered the first necessary intermediate maturation step before either LDCVs or SVs gain fusion-competence and release their neurotransmitters.
These catecholamines could be released to modulate the immunological competence of scallops [4], [46], [47], [48], [49], [50], [51], and help shifting immune function into the most optimal configuration depending on the physiological context [52].
Recent work published by our group presented a visualization of short, plaited pilus structures formed on the bacterial cell surface during competence, and rapidly released from the bacteria 9. Pilus shedding directly correlated with transformability, which led to the proposal of the "Hole in the wall" model (Fig. 4).
Freedland, who serves as a Rangel spokesman, said his campaign had no plans to release documentation attesting to his physical or mental competence, and after repeated requests did not provide information on Rangel's most recent professional evaluations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com