Sentence examples for relax negative from inspiring English sources

The formation of triplex DNA is able to relax negative supercoils such that covalently closed plasmids can fluctuate between being partially relaxed and supercoiled [18].

Thus, DNA topoisomerases, which relax negative and positive DNA supercoils, are important in transcription regulation.

Indeed, whereas Topo IA can only relax negative superturns, Topo IB can relax both positive and negative superturns in vitro.

The V1r1 clade exhibits a relatively relaxed negative pressure, with on given branches, specific residues under positive Darwinian selection, a situation observed for some mammalian V1rs.

However, by examining pairs in which the significance of the correlation coefficients is modestly relaxed, negative correlations do tend to predict targets and positive correlations tend to predict physically proximate pairs.

For strict and relaxed negative selection, the average omega value over respective selection classes is shown.

The terms most commonly associated with dimension one were confident and curious (positive) and unsure and nervous (negative) and those most commonly associated with dimension two were agitated, and angry (positive) and calm, and relaxed (negative).

This was recently followed by data from Kappler and colleagues, who found that, after relaxing negative selection in a mouse model, the resultant T-cell repertoire was substantially more cross-reactive than normal [ 59].

Underwinding (i.e., twisting in the direction opposite to the handedness of the helix) causes the DNA to relax into negative supercoils and destabilizes the hydrogen bonds between bases, increasing the probability of transient local melting.

Apart from NAPs, the maintenance of the chromosome supercoiling in bacteria is controlled by topoisomerases that either relax the negative supercoils (type I topoisomerase) or serve to introduce them (ATP consuming type II topoisomerase), hence linking the energetic metabolism of the cell with the DNA topology [ 36].

Escherichia coli topoisomerase I (EcTopo I), a typical type IA topoisomerase, can only relax DNA with negative supercoiling and require single-stranded DNA regions for its activity [ 13].