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These data may reflect chance concurrence of primary headache syndromes, for although they derive from prospective studies they involved relatively selected patient populations, namely neurology outpatient clinic attenders.
Our cohort is relatively selected, but this patient group is expected to have excess mortality compared to the general population.
Although the analysis included a large sample of 11 234 patients with T2DM, its applicability to the general population of patients with T2DM might be limited by the relatively selected patient populations in the included trials.
48 49 There might be some limitations in applying the findings of the present analysis to the general population of patients with T2DM because of the relatively selected patient populations in the included trials, which included mostly white, middle-aged patients with mean baseline HbA1c <9%.
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What is notable, then, is that nearly all boundaries in Cryptococcus – relatively weakly and relatively strongly selected – are preserved by selection.
Thus, it may be difficult, using our approach, to confidently assert that a genomic window contains no functional sequence a window experiencing selection at relatively few selected sites will be difficult to distinguish from an unconstrained window.
I reported in my recent book "The Bin Ladens" that Haqqani was then a "unilateral" asset of the C.I.A., meaning he was one of a relatively select number of warlords who worked directly with the Agency and received hundreds of thousands of dollars in cash to support his war-fighting.
As highly trained professional right-handed jazz pianists constitute a relatively select study population, the present study was limited to six musicians.
They provide empirical support for the basic epidemiological principle that results based on internal comparisons remain generalisable even when study subjects are drawn from a relatively select group.
With our relatively select and small sample, some caution is warranted in generalizing our findings to other older populations and care settings including those in rural areas, in long-term care institutions and with moderate to severe cognitive impairment.
Although these findings support the principle of generalisability of findings from a relatively select group of participants, it remains possible that they are less applicable to smaller, less heterogeneous studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com