Sentence examples for relatively narrow dose from inspiring English sources

Spleen volume changes may be dose sensitive within a relatively narrow dose range.

The TDI was derived from LOAELs (lowest observed adverse effect levels) for a variety of adverse responses in experimental animals that occur in a relatively narrow dose range (WHO 1998).

The current paradigm in regulatory toxicology of only testing a few very high doses of chemicals within a relatively narrow dose range (with the highest dose being the maximum tolerated dose) thus does not serve to predict the hazards posed by low-level exposure to numerous EDCs found in most people in biomonitoring studies conducted in the United States and elsewhere (Calafat et al. 2008).

10– 15 Second, in the Cox regression model, because the radiotherapy dose is high, we neglected the fact that there was a relatively narrow range of dose, and we did not investigate the effect of total radiation dose on treatment outcome, which may obscure the important dose response effect addressed by Willner et al. 17 Thus, the total dose of radiotherapy still should be emphasized.

An apparent linear relationship may describe studies where the range of doses used is relatively narrow (e.g., clinically used doses) but should only be used for interpolation rather than extrapolation of drug effects beyond the dose studied.

It is important to emphasize that the findings of the present review apply only to the relatively narrow question of the dose-response relationship between serum TCDD levels and DM.

Although the margin of safety between effective and potentially toxic doses of oxygen is relatively narrow, the ability to carefully control its dose, meticulous adherence to currently accepted therapeutic protocols, and individually tailored treatment regimens make it a cost-effective safe drug.

Oxygen is an essential substrate for the brain; however, the safety margin between effective and toxic oxygen doses is relatively narrow.

Fortunately, the actual time of sampling was recorded, and we were able to adjust for this variability in sampling time by only comparing bevacizumab concentrations collected within a relatively narrow time window around the end of a dosing cycle (21 days after dose), such as days 19 to 23, which is adequate given that bevacizumab has a long half life of 20 days.

Despite the use of tumor-specific antibodies, the emerging clinical data with ADCs indicates that adverse effects frequently occur before ADCs have reached their optimal therapeutic dose, resulting in a relatively narrow therapeutic window.

Because the margin of safety between the therapeutic and the toxic doses of glycosides is relatively narrow, they must be used carefully.