Of the ten oppositely differentially expressed loci identified in the light vs. dark study, five are predicted to have relatively major effects on the amino acid sequence of the encoded protein, including or excluding large proteins segments, while four have more moderate effects on protein structure, changing small protein-coding exons toward the ends of the genes (Figure S1).
This congenic strategy was considered ideal, since initial estimates suggested the involvement of a relatively few major effect genes, thus requiring the construction of essentially Mendelian-like strains to facilitate gene identification.
SEC flow rates were such that shear scission of glycogen (which is a relatively small molecule) was not a major effect.
And while individual genes underlying a portion of the genetic variance for complex traits have been identified in many studies, in general, there are relatively few genes that have a major effect.
Apparently, having only a relatively small subset of neighbors already achieves the major effect also attained by VNS.
Our samples provided sufficient power to detect relatively small relative risks, and therefore suggest that rs16944 and rs1143634 have no major effect on schizophrenia susceptibility in Asian populations, which is consistent with the previous Asian findings [ 21- 23].
Thus, although paracrine factors of M2 macrophages have relatively little effect on unstimulated fibroblasts, they can have a major effect on fibroblasts with an inflammatory phenotype.
However, the mortality rate in this relatively young cohort is quite low, thus ruling out a major effect of survival bias on our results.
The mutation of SCR was relatively easy to analyse because its loss of function has a major effect on self-compatibility.
I examine first two relatively uncommon types of cancer for which new treatments have had a major effect on survival: namely cancer of the testis and Hodgkin's disease.
