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Degradation on the application site, cutaneous biotransformation, binding of IVM to the haircoat and/or sebum are probably responsible for the relatively lower bioavailability of IVM in horses after pour-on administration.
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Health risk assessments are usually based on unchanged bioavailability of soil-absorbed pollutants, e.g., heavy metals, neglecting interactions of metals with the soil matrix, which may lead to relatively lower bioavailability.
These data suggest that the greater weight loss observed in almond consumers may have been secondary to greater satiety and the lower bioavailability of calories from nuts.
Protein from plant, as opposed to animal, sources may be preferred in chronic kidney disease (CKD) because of the lower bioavailability of phosphate and lower nonvolatile acid load.
This observation suggests a somewhat lower bioavailability of Gla-300 compared with Gla-100.
The unexpected lower bioavailability of iron from the powdered supplement is contrary to previously published reports.
The most likely explanation for this observation in dogs would be a lower bioavailability of phenobarbital from Phenoleptil® vs. Luminal®.
The most likely explanation for this observation would be a lower bioavailability of phenobarbital from Phenoleptil® vs. Luminal®.
One possible explanation could be that, as for other drugs, HIV infected patients present a lower bioavailability of RBV [ 18].
The reasons are not obvious, but could be explained by lower bioavailability of the drugs in some patients.
The exposure to desbutyl-lumefantrine was also decreased by concomitant treatment with nevirapine, due to the lower bioavailability of lumefantrine.
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