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As shown in Figure 4A, the Aβ group without sample treatment showed an increase in AChE activity, while the pretreatment groups with the NAF had relatively inhibited AChE in the brains of the mice.
However, we found no change in tau aggregation (data not shown) but did detect reduced expression of the tau-phosphatase PP2a in animals lacking Irs2; this latter observation may, as suggested by others [9], underlie the increased tau phosphorylation seen in Irs2 −/− animals even though the tau-kinase glycogen synthase kinase-3 (GSK-3) was relatively inhibited (Fig. 2).
Under ++P stress however, the shoot gradually showed signs of wilting with some yellowing of the leaf and relatively inhibited root growth.
Hyperthermic treatment of malignant tumours is one cancer therapy by which the possible mechanism of the proliferation of tumour cells is relatively inhibited (Urano et al, 1983; Cellier et al, 1993).
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Ketoconazole is relatively unselective, inhibiting both cholesterol side chain cleavage and 11 β-hydroxylation (Loose et al, 1983).
However, these therapies do appear to relatively effectively inhibit some types of tumors (at least initially) with the BRAF V600E mutation, and some second-generation inhibitors of BRAF have been reported that do not result in paradoxical activation of cell proliferation in cells expressing KIAA1549 BRAF fusion proteins [ 60].
The selective iNOS inhibitor W1400 in relatively large doses inhibited in a non dose-dependent manner.
PP1 inhibited relatively few kinases in a panel profiling of over 70 protein kinases at University of Dundee [ 29].
The maximum antimicrobial activity was found in the acetone extract of the lichen Cladonia furcata, which, in relatively low concentrations inhibited the tested bacteria and fungi.
Together, these data demonstrate that this new 3-base pair insertion in MEK1 confers resistance to several MAPK pathway inhibitors in vitro, yet can be inhibited relatively effectively by trametinib alone but more profoundly by a combination of dabrafenib and trametinib.
The hydrogenation of the obtained cyclo-octene is relatively slow and strongly inhibited by the presence of the cyclo-octadiene.
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