Bioinformatics approaches are often associated with a relatively high false negative and false positive rate.
However, FOBT presents relatively high false negative and false positive rates, and it has particularly poor sensitivity for the detection of early-stage lesions [ 9- 11].
This test is complicated by relatively high false positive and false negative rates, 8 9 10 so it is almost always followed up by the "gold standard" test of 24 hour urine collection.
The PSA test has relatively high false positive and false negative rates, prostate biopsies can miss cancers, and the highly variable nature of prostate cancer means there is potential for diagnosis of indolent cancers that may never present as a problem [ 6, 7].
However, a substantial number of differentially expressed genes (4,149) measured on at least two microarray platforms were not identified as such by MPSS, and a significant number of MPSS differential transcripts (2,440) were not confirmed on any array, implying a relatively high false positive and false negative rate of the MPSS methodology.
Based on the clinician's perspective, a relatively higher false positive rate is better than false negatives because the latter can cause an infectious TB to spread.
In comparison studies [ 26], this method was shown to outperform other prediction algorithms with the highest Mathews correlation coefficient (0.474) and relatively low false negative rate (5 %) and false positive rate (57 %).
Statistical analysis of gene expression identified nearly 19,000 genes that were differentially expressed between at least two stages, even when a relatively stringent false discovery rate cutoff of 0.001, corresponding to roughly 1 in 1,000 false discoveries, was applied.
Ahmed et al. [9] employed a Bayesian updating approach and increased the crash prediction accuracy up to 72% with a relatively high false alarming rate 42.01%.
In conclusion, the questionnaire was accurate and reliable in diagnosing migraine (agreement level excellent), less so, but adequate, for TTH (sensitivity relatively low, false negative rate relatively high and agreement level fair to good).
