Even though structural analysis clearly identified two sets of interactions of ADP with PKA in the intermediate, one set turns out to be relatively unimportant energetically.
Likewise, in brown trout, Salmo trutta, the frequent necessity to defend a territory against intruders when growing up in natural streams promotes the ability to solve territorial contests fast and by expressing relatively few energetically costly aggressive behaviours, when compared with hatchery-reared young (Sundström et al. 2003).
Fortunately, in the case of oligosaccharides, there are relatively few energetically accessible conformational states for each glycosidic linkage, and thus it is often possible to achieve good conformational sampling from an MD simulation of between 10 and 1000 ns, depending on the size and complexity of the oligosaccharide.
It was shown that the mechanism behind this phenomenon was based on the nucleation and growth of the recrystallized state without preferred orientation in an energetically relatively homogeneous microstructure.
Model calculations suggested that a hemifusion diaphragm is an energetically relatively stable, long-lived intermediate, and that the direct pathway from stalk to fusion pore may be faster (Kuzmin et al., 2001).
Recall that the enzyme activity part of the trade-off is a physico-chemical necessity: an efficient ribozyme needs to be relatively compact and energetically stable, in order to present the required spatial configuration of critical residues in a steady structure for executing the reaction it catalyses.
'Over-ocean flocking' is a relatively safe but energetically-expensive alternative to roosting during the high tide period.
'Over-ocean' or 'high tide' flocking is a relatively safe but energetically-expensive alternative to roosting during the high tide period.
Mr. Zapatero smiled often on the campaign trail, spoke energetically and wore relatively hip clothes.
Accordingly, the formation of the mitochondrial and nuclear proteins are energetically favored by relatively reducing and oxidizing conditions, respectively.
