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Previous data suggests that normal ER+ cells may represent either relatively differentiated luminal cells with limited progenitor capacity or primitive progenitors with stem cell properties in the luminal cell compartment [4], [24], [25].
Expression of Bcl-2 in the second year post-diagnosis also followed the same trends as it had throughout the first, in that the vast majority of the tetramer+ cells fell into the relatively differentiated Bcl-2low subpopulation [37] while the overall CD8 T-cell population was more evenly split between the two, and the relative proportions did not change significantly (Fig 3C, D).
PanD3 tumours were strikingly similar to the patient's original tumour and relatively differentiated.
Analysis of normal human breast tissue reveals a similar hierarchical organisation composed of nonclonogenic luminal cells, and relatively differentiated (EpCAM+CD49f+ALDH-) and undifferentiated (EpCAM+CD49f+ALDH+) luminal progenitors.
A few BrCSCs locate inside the core of tumorsphere (viewed as an atomic nucleus) and a large amount of relatively differentiated progenies surround the outer layer (viewed as electrons).
It might be that the Intrex [ 24, 25] is a particularly sensitive instrument for showing fluctuations in the therapeutic relationship as it measures patterns of the therapeutic relationship (the interaction between therapist and patient) directly and in a relatively differentiated manner.
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So far as the physical world is concerned there is the same law of evolution from the relatively less differentiated, more determinate, more coherent whole and looked at from this point of view man's life and body are but a part of the universe suffering the same process of growth and decay.
Since undifferentiated cells are targets of NK cells, it is logical that NFκB knock down cells are found to be more susceptible to NK cell mediated cytotoxicity since this process may revert the cells to a relatively less differentiated state and be the cause of activation of NK cells.
The progression rate was prolonged in relatively well differentiated as well as in receptor rich tumours.
However, CD133 expression was also detectable in PTCs, even though this type of thyroid cancer is relatively well differentiated.
To reduce the computational burden during analyses we included a subset of 18 specimens, because individuals either shared identical mitochondrial haplotypes or were relatively weakly differentiated.
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