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It may reduce cardiac output and O2 delivery relative to tissue need.
Low mixed Central venous O2 saturation (ScvO2) has been used to optimize cardiac output and O2 delivery relative to tissue needs.
We therefore chose to express mRNA data relative to tissue weight as we have done previously.
On average, the lymphomas contained 1.9-fold more RNA relative to tissue mass, and relative to genomic DNA mass.
Cancellous bone morphometric indices, assessed using 3-dimensional image reconstructions, included bone volume relative to tissue volume (BV/TV, %), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp).
However, as we have previously observed, the expression of these "housekeeping" genes were influenced by the intervention [3] [4] with significant changes following strength training and hindlimb unloading in RPLP0/GAPDH ratio and GAPDH and RPLP0 mRNA relative to total RNA and relative to tissue weight.
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Values normalized to Tbp mRNA are expressed relative to tissues from control mice.
These data suggest a stronger selective pressure on pleiotropic binding sites relative to tissue-specific sites.
Although higher conservation among CTCF-binding events, relative to tissue-specific TFs, could be due solely to the information content or length of the bound motif, we found that conservation of CTCF-binding events across mammalian genomes is not purely the result of a longer target motif.
This suggests that all tissues of neural origin possess a major subset of genes that are strongly differentially expressed relative to tissues of other origin.
Indeed, the limited number of studies that have characterized the NAT tissue relative to healthy tissues have focused on breast tissue, where healthy marginal tissue samples can be readily obtained from reduction mammoplasty and prophylactic mastectomy5,6,7.
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