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In contrast, two markers of early smooth muscle lineage progression, myocardin and SM-α-actin, were significantly elevated in the "stripe" pattern relative to the "loop" pattern.
Ligand binding in hDHFR occurs through a hinge opening motion of the adenosine subdomain relative to the loop subdomain, rather than from the conformational sampling of the Met20 loop as in ecDHFR.
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Significance of enrichment within the S/MARs relative to the loop-enriched regions (compare Supplementary Material, Tables S1 and S2) was calculated by chi-square at 95% CI (1 df).
The percent enrichment of either loop or matrix relative to the total loop plus matrix template was then calculated.
In contrast, the structure of the Y75 loop remains nearly unchanged relative to the Y75 loop in wt HasAp.
Surprisingly, relative to the single loop model, the two related circuits of multi-loop structure (EP and EI) demonstrate opposite sensitivity to internal parameter variation (Figure 2).
Since the microwave frequency modulation (GHz) is fast relative to the feedback loop (1 kHz), polarizability can be collected simultaneously with standard molecular topography images.
Relative to the DE loop, residue 95 is located on the opposite pole of the β2-m tertiary structure; in the crystal packing, however, the two regions, from spatially neighbouring molecules, fall close to each other, hence the observed flexibility of the C-terminal region may affect the conformational flexibility of the DE loop.
This method can greatly accelerate diagnosis relative to the open-loop approach, but requires online optimization.
(C – F ) Comparison of the orientation of helix α2 relative to the P-loop, for various crystalized states of kinesin.
As can be seen, the location of the γ-phosphoryl group relative to the P-loop and upper 50 kD section of the motor domain is very similar in the S236A·MgAMPPNP closed complex and in the S1dC·MgATP open complexes.
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