The method assumes that LNC proliferative responses are causally and quantitatively associated with the effectiveness of sensitization induction (ECETOC, 2003, 2008), yielding results that quantitatively describe relative sensitizing potency, which correlates with human sensitization thresholds (Loveless et al., 2010; van Loveren et al., 2008).
This hypothesis is supported by results by Tulic et al. showing that the timing of endotoxin exposure relative to sensitization could prevent or increase allergic and asthma responses in animals.
One possible patho-physiological mechanism explaining differences in the location of the TrP referred pain can be related to a different clinical manifestation or degrees of trigeminal brain stem sensory nuclear complex sensitization relative to cervical/spinal sensitization.
In addition, these findings suggest that PNT may provide a useful means to ascertain the relative contribution of central sensitization in patients with a complex pain etiology.
After sensitization, the relative corrosion resistances of low-angle grain boundaries, Σ3 boundaries, and Σ9 boundaries were 100%, 95%, and 25%, respectively, while Σ27 boundaries, other low-Σ boundaries and random high-angle grain boundaries had no resistance to corrosion.
The aim of this study was to determine the relative importance of Ca2+ sensitization, ion channels, and intracellular Ca2+ ([Ca2+]in in the mixed constrictor/relaxation actions of superoxide anion on systemic and pulmonary arteries.
An important feature of HT screening is that, due to the interpretation of the β i 2 treat (treatment sensitization effect relative to a positive control), one is mostly interested in β i 2 treat > 0 This implies that inference needs to be one-sided.
Patients from 4 prospective multicenter studies were pooled and segregated according to indicated diagnoses, and then analyzed to assess therapeutic effectiveness of PNT relative to the degree of central sensitization associated with these diagnoses.
Importantly, depletion of BRCA1 conferred a minimum of 2.5- to 3-fold (MDA-MB-231 and U2OS) and a maximum of 8- to 10-fold (HeLa) sensitization to both drugs relative to control cells.
Here, we have employed tissue-specific deletion of GSK-3α, to examine the relative contribution of two insulin-sensitive tissues, muscle and liver, towards the insulin sensitization phenotype originally observed in the global GSK-3α KO animals.
