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Indeed, protein models derived by estimating the relative rates of amino-acid substitution in large protein databases consistently show dramatic differences in the relative replacement rates of different residues (e.g. [9] [11]).
It is well known that the accuracy of phylogenetic reconstruction, i.e., the precision of estimated branch lengths, considerably increases when models of relative replacement rates of amino acids, specific to a particular protein family, are examined [ 28, 29].
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Each state is typically assigned a numerical vulnerability value such as repair cost, damage ratio (repair cost relative to replacement cost) or percentage of damage.
We have never had a stock market trade at such a high value relative to replacement cost [of assets], says Richard Howard, portfolio manager for T. Rowe Prices Capital Appreciation Fund.
Substitution patterns indicate the important role of purifying selection governing mitochondrial genome evolution, and the most apparent lineage-specific patterns of variation within F. heteroclitus is an excess of synonymous relative to replacement polymorphism in the Georgia population.
Other valuation measures, such as Robert Shiller's cyclically adjusted P/E ratio, and the late James Tobin's "Q ratio" — which measures the price of investment assets relative to their replacement cost — are also emitting warning signals.
For a quite a while now, analysts who take seriously such valuation ratios as the price-to-earnings ratio and Tobin's "q" ratio (which measures the price of investment assets relative to their replacement cost) have been warning about a crack in the market.
The comparison of carbonation coefficients of concrete exposed to different environmental conditions indicates that the rate of carbonation is primarily governed by the extent of clinker replacement, relative humidity and water to cement ratio.
Those in urban areas got greater provision of knee replacement relative to need.
The most striking reductions were in renal failure requiring renal replacement (relative risk reduction 88.5%), respiratory failure (79.1%) and severe sepsis (74.3%).
Thus, a gene under strong constraint will show a lower relative proportion of replacement polymorphic changes when compared with the genome-wide average.
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