Exact(4)
The relative pathways were also illustrated in the view of key enzyme activities and the expression levels of key proteins and verified using the corresponding inhibitors.
The complete list of the objective reactions, with relative pathways and synergistic inhibitions, is reported in Additional file 1: Table S2: this list contains many inhibitions in the fatty acid, cholesterol and carnitine transport pathways, which may represent solutions for obesity.
The subset of DE microRNAs showing association with cardiac index (miR-338-3p, miR-142-5p and -3p, miR-216a-5p, miR-223-3p, miR-378g5p, miR-378g) or with pulmonary vascular resistance values (miR-29b-3p miR-374b-5p miR-374b-5p miR-374b-5ped through bioinformatic tools in order to identify putative targets of miRNA regulation and relative pathwass enrichment.
Kersten et al. observed that in fasted mice the simultaneous increase in ketone body concentration and decrease in urea concentration are due to the action of a single factor, PPARα, which regulates the transcription of genes involved in the relative pathways, up-regulating fatty acid oxidation genes and downregulating the ureagenesis and ammonia detoxification.
Similar(56)
A relative pathway connectivity score was used to rank upregulated pro-cardiac transcripts according to the degree of connectivity via hubs to highways of cardiogenic specification (Equation 3).
Bayesian fitting of binary probit regression models to the training data then permits an assessment of the relevance of the metagene signatures in within-sample classification, and estimation and uncertainty assessments for the binary regression weights mapping metagenes to probabilities of relative pathway status.
The pattern of DHCR24 expression in tissues was an imperfect predictor of relative pathway utilization.
We did not see an obvious relationship between concentrations of sterol intermediates and relative pathway utilization.
Bioinformatics' tools were then used for prediction of putative targets of modulated miRNAs and relative pathway enrichment.
The relative pathway abundance of higher order functional categories were calculated from normalized KO abundance in humans and guinea pigs.
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