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We find that the mechanophore activation length relative to the debond length is critical in determining the relative onset of debonding and activation.
Again, Fig. 5 shows a minimum curvature fit to the relative onset times between each period band.
Latencies were divided by the concurrent TA cycle duration to obtain relative onset latencies.
The relative onset plot (Figure 5A3, right plot) revealed that the burst onsets sorted as early (open circles) and late (closed circles) in the TA cycle.
Collectively, FT exhibited a distinct relative onset bias (>60% of sample) in 9 of 10 control experiments, and a preference for early onset (7 experiments).
LG onset closely varied with cycle duration and a late relative onset was the predominant pattern in 4 of 6 foot-free experiments.
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Relative onsets fell mostly between 0 0.2 across a TA frequency range of 1 7 Hz (Figure 3B2).
Relative onsets fell mostly in the latter half of the TA cycle at all RLM frequencies (Figure 3C2).
In the latter experiment, FT bursts began early in cycles 2 6 (Figure 4B1), and during the experiment relative onsets fell mostly between 0.2 0.5 over a frequency range of 2 8 Hz (Figure 4B2, bottom plot).
TO is a potent, reversible NEP inhibitor with a relative rapid onset of action [21], but its water solubility is not ideal for iv injection as a bolus together with the radiopeptide.
Similarly, orange traces in Figure 6C (right panels) show changes in firing relative to onset of a bout of licking for liquid food.
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