HAdV-53 was reported as a novel recombinant HAdV with a close genetic relationship to loop 1 and loop 2 of HAdV-22, the penton base gene of HAdV-37, and the fiber gene of HAdV-8.
It also sounds like this deepens an existing relationship, with Loop previously making a minority investment in ScreenPlay.
An S-shaped relationship between loop of Henle perfusion rate and single nephron GFR in rat has been reported [ 24].
For the reviewers' interest, we point to the excellent papers by Leo James, cited in the original manuscript, on the relationship between loop states, CypA/TRIMCypA lineage, and binding.
Some evolutionary relationship between loop states and Gag binding might hold, but there are no lineage data cited even to hint at such a possibility.
However, the CDR3 loops of the remaining TCRs, which range from seven to eleven amino acids for CDR3α and six to nine amino acids for CDR3β, show no relationship between loop length and structural shift.
Therefore, we have rewritten the manuscript to remove the indications of cause-effect relationship between looping and gene activation.
The manuscript should be rewritten to remove all indication of cause-effect relationship between looping and gene activation.
This is a massive misinterpretation of data, because there is no experiment showing a cause-effect relationship between looping and gene activity, only a correlation.
The applications of feedback loops, which specify the causal relationship in a loop, can explain the ecological dynamics in a cyclical perspective.
