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Finally, we sought to determine whether the depression-adherence relationship differed depending on the strength of study methodology, i.e., is the relationship attenuated in more rigorous studies or does stronger methodology reveal a larger relationship?
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In the pooled data, while unadjusted relationships found IPV to be associated with a small, significant increase in HIV prevalence (OR between 1.06 and 1.20), these relationships attenuated into insignificance once adjustment was made for demographic and social factors (OR between 1.02 and 1.05).
Food insecurity was also associated with uncontrolled eating (p ≤ 0.05), but the relationship was attenuated when controlled for potential confounding variables.
Two months after discharge, more frequent post-operative complications predicted higher pain levels in a univariate analysis (p=0.02) although this relationship was attenuated after adjustment for depression.
In each case, increases in the biomarker had a stronger association with pump failure than sudden cardiac death, but this relationship was attenuated after adjustment for clinical risk factors.
Compared with those in the lowest quartile of nighttime to daytime SBP, those in the highest quartile were more likely to develop preHTN/HTN (HR 1.61; P =.06), but this relationship was attenuated after adjustment (HR 1.34; P =.27).
However, a recent ICU-based study demonstrated that although persistent AKI was associated with an increased risk of in-hospital death, this relationship was attenuated after accounting for AKI severity [8].
Furthermore, the prevalence of LVH increased significantly with ascending tertiles of log FGF21 in univariable analyses (Table 2), but this relationship was attenuated after multivariable adjustment.
Using a dominant genetic model, rs688 genotype remained significantly associated with %LDLR12 after statin treatment, however this relationship was attenuated compared to that with baseline %LDLR12 (Figure 8D).
An inverse association between olive oil consumption and depression was also found, although this relationship was attenuated after adjustment for the adherence to a Mediterranean Dietary Pattern.
This relationship is attenuated by ischemic heart disease and by depression in particular.
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