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Ginkgetin inhibited Wnt pathway with an IC50 value around 5.92 μM and structure activity relationship analysis suggested the methoxy group in Ginkgetin as a functional group.
Structure activity relationship analysis suggested that introduction of a fluorine atom at the 3′-position of benzene ring of the phenylacetyl moiety significantly increased affinities to the enzyme.
A structure activity relationship analysis suggested that the electron density of aromatic ring which was linked with tacrine through acetyl group played a significant role in determining the inhibitory activity.
Structure activity relationship analysis suggested that the molecular size of acyl moieties at C-4 and C-9 position might have an effect on the activity of this type of coniferol derivatives.
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Structure activity relationship analysis suggests that steric structural arrangement within the C17 side chain is important for differentiating cytotoxic and anti-angiogenic activities.
Structure activity relationship analysis suggests the existence of a specific target molecule for ATL cell-selective inhibition of proliferation through G2 arrest.
Orthologous relationship analysis suggests that these two R-gene loci in watermelon were translocated (alternatively, the corresponding two loci in cucumber/melon were translocated).
MOE-based Quantitative structure activity relationship (QSAR) analysis suggested that electrostatic and hydrophobic interactions and lipophilicity are important factors for CYP inhibition.
The structure-activity relationship (SAR) analysis suggested that the compounds derived from thiophene chalcones (6 17) exhibited generally better antiproliferative activity than those derived from bioisoteric replacement of furan chalcones (18 29) on MDA-MB231 breast cancer cells.
The initial structure activity relationships (SARs) analysis suggested that further development of such compounds might be of interest.
The preliminary structure activity relationships (SARs) analysis suggested that (1) 1-amino substituents were the advisable pharmacophoric group for enhanced cytotoxic activities; (2) the introduction of appropriate arylated alkyl groups into position-9 of β-carboline facilitated their cytotoxic potencies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com