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Structure activity relationship analysis revealed that appropriate substitutions at C-6 positions contributed to the kinase inhibition and antiproliferative effects.
Furthermore, structure activity relationship analysis revealed that hybrids with trans olefinic bond group were more active than those without olefinic bond, and we found that the methoxy substituent could enhance cytotoxicity selectivity of GA CA hybrids.
Structure activity relationship analysis revealed that a 3-hydroxyl group in ring C and a 2′-fluoride group in ring B were essential for this class of compounds to be active against NMU2R.
The structure-activity relationship analysis revealed that, for the enhancement of inhibitory action against MMP-9 enzymatic activity, demethylation at position 4′ in B-ring was a key structural modification in Müller cells, which are an important source of MMPs found in vitreous fluid and retinal tissues in retinal proliferative diseases.
Structure activity relationship analysis revealed not only that the presence of the quinoline ring is crucial for dual activity but also that the substitution position plays a decisive role in the neurotrophic effect.
Relationship analysis revealed that MAWD and MAWBP expression was significantly correlated with the expression of TGF-beta (P < 0.001) and E-cadherin (P < 0.05) (Tables 3, 4).
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A qualitative structure-activity relationship (SAR) analysis revealed that the Cl substituent and its position at the pyridine ring were crucial for the compounds' activities.
Structure activity relationship (SAR) analysis revealed that flavanone derivatives showed the most potent activities, while flavone and chalcone derivatives exhibited medium activities.
The structure activity relationship (SAR) analysis revealed that the introduction of the benzo[1,3]dioxol moiety in 3i and the 4-morpholinyl-4-phenyl moiety in 3s has proven to give the most potent compounds in this study.
The structure−activity relationship (SAR) analysis revealed that introduction of a substituent at the 8-position in pseudoprotoberberine, especially an n-decyl, could significantly enhance the anti-TB activity.
The structure activity relationship (SAR) analysis revealed that (i) the order of anticancer potency for the 3-haloacylamino chain was following –CH2Br > –CHBrCH3; (ii) the N′-substituent moiety was not essential for the anticancer activity, and a proper alkyl substitution might enhance the anticancer activity.
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