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The aim of the study was to evaluate potential prothrombotic alterations in acute myocardial infarction patients in relation to hyperglycemia, including thrombin formation, platelet activation, and fibrin network structure/function.
In contrast to microangiopathies (e.g. nephropathy and retinopathy), where the causal relation to hyperglycemia is well supported, the link between hyperglycemia and macroangiopathy is uncertain, at least in terms of the possibility of reducing macrovascular morbidity solely by reducing hyperglycemia.
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The aim of the present study was to further investigate monocyte atherosclerosis related integrin subunit changes in relation to diabetes and hyperglycemia.
Although various histone modifications have been demonstrated in vitro in relation to complications of hyperglycemia (Wierda et al. 2010), permanence of individual changes has not been established.
However, clinical and experimental studies have reported contrasting evidence in relation to the effects of hyperglycemia on BBB permeability and function.
Similarly, disparate evidence from clinical and experimental studies has been reported in relation to the effects of hyperglycemia on BBB glucose transporters (mainly GLUT-1) expression and nutrient transport.
These data are discussed in the context of the fundamental role of hyperglycemia in relation to metabolism-dependent formation of reactive oxygen species.
Volunteers with the highest smoking rates had an OR of 1.7 for hyperglycemia in relation to non-smokers, showing the effect of smoking load on glucose and lipid metabolism in the sample of subjects.
The objective of the present study was to investigate the occurrence of hyperglycemia in relation to the insulin response and exogenous factors, such as glucose intake and drug use, in a homogenous group of critically ill children with meningococcal sepsis or meningococcal septic shock or both.
The curriculum covered different aspects of diabetes: food recommendations, self-monitoring of BG techniques, insulin profiles, and appropriate management of hypo- and hyperglycemia in general and in relation to stress, infections, menstrual periods, alcohol intake, and exercise.
While there is a lack of consensus in relation to the magnitude of the effect of acute hyperglycemia and the potential influence of chronic elevation of blood glucose, it is clear that marked acute hyperglycemia (i.e., blood glucose level ∼15 mmol/L) delays gastric emptying substantially in both health and type 1 diabetes when compared with euglycemia (∼5 mmol/L).
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