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These observations are discussed in relation to functional specialization as well as functional integration.
The correlations could be due to functional polymorphisms or to population structure.
Genotypes were determined with respect to a functional polymorphism of the serotonin transporter gene promoter region (5HTTLPR).
It is also possible that these SNPs are not the functional polymorphisms but are linked to a functional polymorphism elsewhere in the gene.
Consulting behavior for chronic somatic symptoms was analyzed in the patients with IBS in relation to the val158met polymorphism.
Perhaps the most compelling evidence of phenotypic adaptability is in relation to colour pattern polymorphism.
The purpose of this study was to analyze functional polymorphisms in candidate genes (methylenetetrahydrofolate reductase [MTHFR]677C>T, MTHFR1298A>C, factor 5 1691G>A [FVL], and angiotensinogen (AGT -6G>A) in relAGT -6G>Aa hypothesined placental hemorelationatoway to preterm delivery (PTD).
To investigate uterine leiomyomata (UL) incidence in relation to polymorphisms in genes involved in vitamin D metabolism and skin pigmentation.
Mikko Niemi (University of Helsinki, Finland) discussed statin-induced myopathy in relation to polymorphisms in transporter genes.
In relation to the GSTT1 present/null polymorphism, two meta-analyses and three pooled analyses have been performed to date.
Interestingly, this Val108/158 Met functional polymorphism has been reported to be associated with schizotypal personality traits even in healthy individuals, and in the same direction as observed in schizophrenic patients, that is, increased Val allele frequency (Avramopoulos et al, 2002).
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