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Several genetic determinants relating to proliferation and growth, invasion and metastasis have been identified.
This identified gene expression patterns relating to proliferation and differentiation within benign prostate epithelium.
Analysis of gene expression by RT-PCR showed that at 5 weeks of age, there were already some changes in the expression of specific genes relating to proliferation (CyclinD1) and β-cell function (Insulin, MafA, PDX1 and Glut 2), with no evident differences in insulin secretory defects between POKO and ob/ob [ 17].
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In fact, when several of the published signatures were divided into partial signatures composed of proliferation-related genes and genes not related to proliferation, the latter failed to show prognostic significance, whereas the prognostic power of some signatures even improved by the removal of genes not related to proliferation [ 30].
There are controversies related to proliferation of dental-derived stem cells under induced hypoxia.
The suppression of DNA synthesis and the G1 to S phase transition due to the expression of proteins related to proliferation and cell cycle progression may contribute to the inhibitory effect of 8b-13 peptides on cellular proliferation.
Once β-catenin is phosphorylated, it detaches from the E-cadherin complex and localizes to the nucleus where it promotes transcription of genes related to proliferation, migration, and invasion [43].
Microarray studies on OE have shown an enhanced expression of genes related to proliferation in schizophrenia patients as compared to controls [43].
As activation of cell-cycle genes is closely related to proliferation we further examined the expression of miRNAs in samples with different proliferative states.
However, unmasking chaotic dynamics is essential for analysis of cellular processes related to proliferation rate, including metabolic activity, telomere homeostasis, gene expression, and tumor growth.
Surprisingly, favourable miRNAs were instead found to be positively associated with cell activities related to proliferation.
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