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Second, the rarity of mutations, especially mutations that are beneficial for fitness, 6, 7 meant that it was experimentally difficult to obtain samples sizes compatible with testing hypotheses relating to mutation parameters.
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The first experiment, named here E2O (Experiment with 2 Objectives), used two objectives related to mutation score and number of test cases, given respectively by Eqs. 2 and 4. The goal is to obtain high scores with reduced cost.
A problem related to "mutation on demand" is that people often think that, whatever situation an organism faces, it will somehow find a solution (e.g., humans will somehow find a way to evolve to tolerate increasing pollution).
Furthermore, the remaining mutation entities without change and location information include terms that are related to mutation.
Distinctive neuropathological features are found in some pathology case reports and may be related to mutation type.
Theoretically, c is related to mutation rate and branch length, and a detailed analysis will be performed in the future.
Several factors are thought to be related to mutation rate, including DNA replication timing [ 2], genetic recombination [ 3], and categorized genomic regions [ 4].
Hence, the gray-level magnitude-based features that were related to mutation status in our study population may not be generalizable to FFDM.
Only invasive breast cancer cases diagnosed before age 70 years were included, to reduce the likelihood of phenocopy tumors not directly related to mutation status.
This group used MethyLight analysis and hierarchical clustering to confirm a CIMP-positive subset of cancers which was strongly related to mutation of the BRAF gene [ 16].
FGFR3 protein expression is strongly related to mutation status, with increased expression in the majority of FGFR3-mutant superficial tumours (Tomlinson et al, 2007a).
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