Another kind of lectin related to complement initiation, mannose biding lectins (MBL), was not detected.
The initiating steps in this proposed model of cumulative subretinal microglia accretion have not been defined but may potentially be related to complement activation [45], drusen accumulation [46], photoreceptor injury [47], or oxidative stress in the outer retina [48].
To determine whether AP of complement activation in AMD patients is related to complement gene polymorphisms previously associated with the disease, all probands were genotyped for six SNPs in the CFH gene, five in BF-C2, and one polymorphism in C3 (Fig. 1 and Table S1).
Degranulation seems to be mediated by a different membrane receptor, not related to complement activation and neutropenia [ 54].
Cardiopulmonary bypass (CPB) is associated with a significant inflammatory reaction which has been related to complement activation, and release of various inflammatory mediators and proteolytic enzymes [ 1].
Many of these effects are related to complement activation during the haemodialysis treatment when the blood is in direct or indirect contact with artificial surfaces such as those of the dialyser, bloodlines and dialysis fluid.
Within this diet group, a strong up-regulation of many components of the immune specific response was evidenced, whereas other genes related to complement response and xenobiotic metabolism were down-regulated.
In aHUS, we need to clarify whether and which secondary forms are related to complement dysregulation.
Genes related to complement activation were upregulated and genes related to mitochondrial electron transport chain were downregulated.
Among genes downregulated by HLA-B*35 lentivirus were genes related to complement (C1QB, C1QC), cell cycle (CDNK1A) and apoptosis (Bax, Gadd45).
