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Although recycling between the cell membrane and endosomal compartments has been demonstrated for MHC-I in both in T cells and macrophages 19, 20, little is known about MHC-I endocytic trafficking in DCs or how this relates to their function in cross-presenation.
The most accurate definition of TFH cells relates to their function that migrates to follicles and interacts with B cells to support B-cell differentiation.
And if, in fact, iRhoms do have a role in mammalian ERAD, there is no understanding about how this relates to their function in forward trafficking of TACE.
More recent work suggests that opposing motor proteins might act in positioning ERES within cells (V. Gupta and D.J.S., unpublished observations) but it remains unclear how the position of ERES relates to their function.
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This chapter provides a brief description of tropomyosin's periodic and aperiodic structural features related to their function.
Microglial movement via this optimal search strategy may be related to their function as immune cells of the brain.
This is particularly the case with man-made manipulable objects such as saw or hammer, whose visual features are directly related to their function.
As for human-made complex networks, their structure is intimately related to their function and they display an emergent behavior that cannot be understood as being merely the sum of the individual actions [25].
Phylogenetic analysis of the Slfn genes indicated that the Slfn gene region, located in an otherwise conserved human-mouse interval, is evolving rapidly, possibly in response to selective pressure related to their function in the immune response [7].
The finding that it exists in all dependence receptors described to date suggests that it may play a role in some biochemical process related to their function, such as the induction of apoptosis or the inhibition of apoptosis following ligand binding, or possibly an interaction with another membrane protein or membrane-associated non-proteinaceous molecule such as a lipid.
The remaining genes have limited information related to their function.
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