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This mechanism relates to receptor shedding, a process used by some cells to regulate signal transduction pathways (Tokumaru et al, 2000; Chen et al, 2001).
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Potencies were not strictly related to receptor binding affinities and not significantly affected by the amount of endogenous GC receptor.
As new structural information becomes available, complementary experimental strategies are required to address questions related to receptor dynamics and organization in membranes.
Lipophilicity (log P) and basicity (pKa) of the newly synthesized compounds were measured and related to receptor affinity in a QSAR study.
Amino acid residues related to receptor binding were identical to those A/Goose/Guangdong/1/96-like viruses (Figure 2) [6], [8], [8].
Signal transduction pathways for ET-1 related to receptor subtypes distribution vary between vascular beds and species [22].
We are presently pursuing the identity of these proteins and it is interesting to speculate that their presence is directly related to receptor activation and or recycling.
Tumour histology may also be related to receptor status.
This domain is related to receptor dimerization, chaperone binding and recruitment of co-regulators [ 21].
In humans and rodents some variations in taste sensitivity have been related to receptor polymorphisms.
Overexpression of KIT and PDGFRA was closely related to receptor mutation status.
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