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The elucidation of the biology of HYAL in the skin may offer novel pharmacological targets to confront age related turnover of HA in skin.
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While the inhibition at pH 9.5 requires enzyme turnover and, hence, is related to turnover, the inactivation was distinctly different from the enzyme activity.
In sum, we propose a moderated mediation model of turnover intention: Employees' psychological ownership is related to turnover intention (partially) via conducting territorial behavior.
Based on this finding, it is reasonable to speculate that PGRN has a lysosomal function related to turnover of lipofuscin-related substrates.
As well, territoriality is negatively related to turnover intention and mediates the relationship between psychological ownership and turnover intention.
Concerning the correlation between burnout and turnover intention, our results confirm that the three dimensions of burnout are positively related to turnover intention, which has been demonstrated in previous studies [ 31, 41, 42], whereby physicians suffering from serious burnout tend to report higher degrees of turnover intention.
In terms of the correlation between job satisfaction and turnover intention among physicians, all subscales of job satisfaction were found to be negatively related to turnover intention, which is consistent with the studies of Shao H et al and Griffeth R.W et al [ 39, 40].
Moreover, job satisfaction was found to be inversely related with turnover of employees [ 28], i.e., poor job satisfaction is linked to high turnover [ 16, 29].
Firm size was negatively related to turnover rates.
Team tenure was positively related to turnover rates, but the relationship was not statistically significant.
Hypothesis 1 posits that employees' psychological ownership is negatively related to turnover intention.
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