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For grade 3 or 4 special adverse events, 15.2% patients presented with acne-like rash, 6.1% presented with nail toxicity (this special event category included the preferred terms nail toxicity and paronychia) and no patient presented with infusion-related reactions (this special event category included the preferred terms "infusion related reaction" and "pyrexia").
A few called it erythema multiforme, which is a closely related reaction that until very recently was considered the same entity as Stevens-Johnson syndrome.
The combinatorial chemistry related reaction enumeration features are considerably enhanced.
These techniques are nowadays frequently used to obtain mechanistic insight into the active site and the related reaction mechanism.
CDK-Taverna 1.0 provided basic functions for combinatorial chemistry related reaction enumeration: They supported the use of two reactants, a single product and one generic group per reactant.
Firstly, considering that OMCs changed during bioleaching process, physicochemical parameters were significantly affected by mineral composition and the directly related reaction might be sulfur/iron oxidization, pH and the concentration of Fe3+ were chosen to represent the OMCs.
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That is, structural features of actual butterfly eyespots must be studied first and then the related reaction-diffusion simulations can be explored.
One SAE (infusion-related reaction) was considered possibly peginesatide related.
A single SAE (infusion-related reaction, described below) was considered possibly related to peginesatide.
Of the AEs that led to patient withdrawal from the study, only the events of rash/pruritic rash and infusion-related reaction were considered by the investigators to be possibly related to peginesatide administration.
One subject in the 5.0 mg/kg/week multiple-dose group reported a grade 1 infusion-related reaction (pruritus and urticaria) that required temporary (48 minutes) interruption of dosing and was judged as probably related to MEDI-546.
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