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The NSGM down-regulated several CSC markers through regulation of gene transcription, while closely related, inactive NSGMs G1.4 and G4.1 demonstrated no such changes.
The identified NSGM down-regulated several CSC markers through regulation of gene transcription, while closely related, inactive NSGMs demonstrated no such changes.
A structurally related inactive analog was unable to promote mitochondrial swelling, highlighting the importance of edelfosine molecular structure in its effect on mitochondria.
This effect of edelfosine on mitochondrial swelling was dependent on its ether lipid molecular structure, as an structurally related inactive analog, ET-18-OH (1- O-octadecyl rac-glycero-3-phosphocholine; Figure 2), in which the methoxy group in the sn-2 position was replaced by an OH group, was unable to induce swelling and apoptosis.
Specific CERK inhibitor NVP-231 [17] and the related inactive compound 4 were kindly provided by Dr. F. Bornancin.
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The historical relationships in SNOMED CT are used to relate inactive concepts to active concepts.
Parallel to behavioral associations, gene profiles were not related to inactive period deep sleep, but were tied to active period deep sleep, particularly among aged subjects.
The high-potency fascin-pathway enhancer mephenesin was compared with the structurally related but inactive guaifenesin (similarity 0.87), which differs only by the replacement of the methyl substituent in the phenyl ring by a methoxy group (Fig. 6C, green circles).
In contrast to a study from a rural community in Pakistan that demonstrates poor awareness about diseases (38), our participants were aware of a rising prevalence of hypertension and diabetes in the community, and believed this was related to inactive lifestyle and unhealthy diet.
The above analyses of cell type-specific genes indicate that, while H3K4me3 signals are generally correlated with gene expression though are sometimes present even in non-expressing cells, changes in H3K27me3 are more closely related to inactive expression states in different cell types.
Negative labels mostly relate to inactive outcomes of the tested compounds in relation to the setup of a particular BioAssay, but since they may indicate an opposite phenotype of interaction (e.g. inhibition vs. activation) in the same assay, we call them negative interactions.
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