Exact(7)
Grey related grade.
Three patients developed neurologic toxicity, including transient delirium (1 grade 2, 1 grade 3) and 1 possibly related grade 5 encephalopathy.
Briefly, motesanib treatment was withheld for suspected or related grade 3 toxicity (other than hypertension) not adequately controlled with supportive care, or treatment-related grade 4 toxicity.
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The dose of S-1 was reduced by 20 mg/day for related grade 3 toxicity.
BEV was held until other related grade 3 events resolved to grade ≤1.
Similar(53)
Panitumumab was held for symptomatic skin or nail-related toxicity or any clinically related ⩾ grade 3 toxicity.
Three therapy-related grade 3 adverse events were reported, one of which (fatigue) was serious.
Treatment-related grade 3-4 AEs occurred in 3.2% of the patients.
Treatment-related grade 3 AEs included diarrhoea, hypothalamopituitary disorder (hypophysitis), colitis, nausea, vomiting, pruritus, and rash.
Treatment-related grade 3 or 4 AEs were observed in seven patients.
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