Exact(2)
The well-characterized Tg2576 mouse model of AD exhibits age related accumulation of Aβ plaque pathology starting at 12 months as well as behavioral deficits evident as early as 3 months of age [24].
The reason for this is thought to be multifactorial, including aging related accumulation of mutations in cellular tumor-suppressive and tumor-promoting (oncogenic) pathways and age-related disturbance of immune surveillance.
Similar(58)
Age-related macular degeneration (AMD) and Alzheimer's disease (AD) are degenerative, multifactorial diseases involving age-related accumulation of extracellular deposits linked to dysregulation of protein homeostasis.
Brunk, U.T. & Terman, A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function.
Brunk, U. T. & Terman, A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function.
Additional studies are required to assess similarities and differences in the age-related accumulation of mutations in muscles other than the vastus lateralis.
ERS-related accumulation of unfolded/misfolded proteins and the unfolded protein response are important signals for the progression of many diseases.
Though, age-related accumulation of PBDEs in fish had been observed [28].
We model the process of aging as the age-related accumulation of damage produced by oxidative stress, which reduces the homeostatic capacity of the organism.
Nonatherosclerotic areas in human arteries display an age-related accumulation of cholesteryl ester in the form of small, perifibrous lipid droplets in the deeper intimal layers.
Optimization of the imaging and interpretation protocols of WBC scans allows an improved differentiation of sterile inflammation from infection-related accumulation of leukocytes [42],[42].
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