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"I can predict to you now that it is likely that the children who look reasonably normal, don't have any gross formation defects, might later on have issues that relate to subtle things like visual defects, or hearing defects, or intellectual landmarks children get as they develop.
These findings suggest that cognitive changes in patients with SLE may relate to subtle changes in white matter.
As the approach to the data analysis was identical the reason underlying this discrepancy is unknown but may relate to subtle differences in the diagnosis and hence classification of pre-eclampsia between data bases, or to the relatively higher percentage of women in our population with a large inter-pregnancy BMI gain (3% more in both initially healthy and overweight categories).
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Understanding how this back-and-forth movement relates to subtle changes in past temperatures may provide important clues to the future.
These deviations were related to subtle variations in column packing, rather than differences in column height.
Unfortunately, while our biochemical work also showed APP to be localized to a small subset of synaptic vesicles (and presumably present in low copy number) we were unable to obtain any evidence for APP being localized to distinct functional pools of vesicles in the synaptic terminal (although this may also be related to subtle trafficking issues with the construct – see below).
This conclusion contrasts with an earlier report of EEG patterns "related to subtle, undiagnosed sleep-disordered breathing" in patients with chronic fatigue [ 31].
In contrast to sICAM-1 and sVCAM-1 (which are also expressed by other tissues) sE-selectin represents a more endothelial specific parameter, which appeared to be related to subtle inflammation as well as to type 2 diabetes development.
Yet, land use intensity changes are often related to subtle spectral changes, and are thus notoriously hard to separate from the background variability in the system (e.g. phenology, atmospheric or topographic effects).
This treatment may also improve quality of life as ALS patients early in their course may experience non-specific symptoms of fatigue and lethargy, related to subtle respiratory muscle weakness, which goes unrecognized or is attributed to impaired mobility[ 2].
Although the molecular basis for this mechanistic switch between PADs 2 and 4 is unknown, it likely relates to subtle differences in the active site architecture because the two enzymes adopt similar conformations in the catalytically competent calcium-bound state.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com