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As an additional parameter to estimate trastuzumab benefits in community practice, the GHEA study also sought to determine whether patients relapsing under trastuzumab treatment differ from those relapsing after the end of the treatment with respect to prognostic factors and site/frequency of distant metastases.
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Fourteen patients relapsed under tamoxifen treatment (relapsing group) and 19 patients did not have a recurrence after 5 years of tamoxifen treatment (nonrelapsing group).
The separate cohort (n = 33) included 14 patients who relapsed under tamoxifen treatment (relapsing group) and 19 patients who did not relapse after 5 years of tamoxifen treatment (nonrelapsing group).
Interestingly, three renal cell carcinoma patients who relapsed under sorafenib were subsequently co-administered radiotherapy [ 12].
Smaller tumors with good prognostic factors tend to relapse under the second peak of the frequency of the relapse curve (at around 5 years).
We also demonstrated the strong prognostic value of the BCL2/ FOS signature in ER-positive patients who relapsed under tamoxifen treatment.
Thus, methamphetamine psychosis and schizophrenia resemble each other in a cross-section of clinical features, e.g., auditory hallucination and delusion, the longitudinal process of progressive exacerbation with acute relapses, good response to neuroleptics, and enduring vulnerability to relapse under stressors.
Importantly, these cells are total populations of AI-resistant cells and may thus also mimic the heterogeneous phenotype and behavior of resistant cells possibly present in the tumors of patients who relapse under AI endocrine therapy.
More recently Retsky and coworkers [ 12**, 38], Demicheli et al [ 39], and Swartzendruber et al [ 40] hypothesized that adjuvant therapy may only benefit those patients who are not cured by local therapy and who would relapse under the first peak of the frequency of the relapse curve (at around 18 months).
Also pancreatic cancer may relapse even under allo-HSCT.
Last but not least pancreatic cancer may relapse even under allo-HSCT.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com