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For the dataset of Wang et al., relapse was used as an endpoint and 286 patients were included in the analysis.
For the dataset of Sorlie et al., relapse was used as an endpoint and 118 patients were included in the analysis.
In survival analyses, the time from surgery to relapse was used to calculate relapse-free rates.
The date of relapse was used to calculate relapse free survival from diagnosis.
Because some patients could not obtain complete remission after surgery, death was used as the primary endpoint in all patients, and relapse was used as the secondary endpoint in patients who could obtain complete resection after surgery.
Time to relapse was calculated from the date of completion of treatment to the date of relapse, with the exception of patients who relapsed following surgery and prior to starting adjuvant radiotherapy, when date of surgery to the date of relapse was used.
Similar(54)
This case definition for relapse is used by the national program and in clinical trials (6 ).
All relapsed patients up till 12/2003 with available information on CD66c expression at diagnosis and at relapse were used to assess stability of CD66c expression.
However, comparisons between these trials and the current study should be regarded cautiously since different definitions of remission and relapse were used.
An independent set of 104 marrow samples acquired at the time of initial diagnosis and 29 samples acquired at relapse were used to confirm the differential miRNA expression pattern and target gene expression by qRT-PCR.
The only factor predictive of higher relapse was use of hematopoietic growth factors to promote engraftment following HCT.
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