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> -wrap-foot> The relapse interval was counted from discontinuation of treatment until the first relapse.
Consequently, using a lower WT1 ratio threshold of 20 will improve the sensitivity and specificity combination and increase the time to relapse interval, without having excessive false positives.
Among eleven patients tested before treatment and at first relapse (interval: 13 +/- 7 months), in vitro CFU-L sensitivity revealed no correlation between the two measurements, and a trend in decreased sensitivity to daunorubicin and ara-C.
Our time-to-relapse estimates for other regions are considerably longer than estimates from earlier studies, with the exception of a study from El Salvador, which reported a median relapse interval of 28 weeks (32 ).
Additionally, the average time to relapse interval is longer for high risk patients (58.1 days, SD=34.9; Table 3) than for the entire cohort (49.1 days, SD=30.8; Table 2).
A recent comprehensive model including multiple relapse states used a 15-day incubation period in simulations to produce a mean relapse interval of 7.1 months for cases in India, with incubation as an exponential distribution, and relapses modeled using a gamma distribution [ 10].
Similar(54)
It also does not explain time clustering of relapse intervals or heterologous genotypes in relapses.
Our finding suggests that these prior estimates for relapse intervals were based primarily on infections with Old World tropical strains.
The estimated median relapse intervals were only 7 months for high-grade subcluster tumours, and 63 months for PUNLMP subcluster tumours.
Published P. vivax models have made a range of implicit and explicit assumptions about the functional form of incubation periods and relapse intervals with limited empirical justification.
Data analysis of the patients in therapy groups showed improvement in HRQoL, prolongation of relapse intervals, and reduction of side effects caused by tumor destructive therapies.
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