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We show that rejection of samples based on our quality control parameters leads to a significant improvement of methylation calling.
The study highlighted that rejection of samples based on cytological criteria would have resulted in some positive samples being missed.
In particular the measurement of multi-allelic CNVs is the most problematic, more specifically those with higher copy numbers, where it is essential that the technical challenges of copy number genotyping are robust for all copy number classes and do not result in the systematic rejection of samples with high copy number.
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Their shared rejection of sampling in their fields proves the most obvious commonality.
While acknowledging that the adoption of the simple random sampling approach to the IIs clearly contradicts the rejection of random sampling for the FDGs, it was necessitated by the fact that almost all the participants in the FGDs also expressed their interests in taking part in the IIs.
Furthermore, the rejection of non-confident samples finally led to a classification accuracy of 80% for the three classes.
This section does not provide specific criteria for acceptance or rejection of the test sample.
This represents a Type I error, the rejection of an authentic sample.
Given a sample of a r a function, we use rejection sampling to draw 1000 samples of g from Eq. 5 [ 40].
Although a range of assignment programs are available (see Hansen et al. 2001; Manel et al. 2005), G eneC lass2 was used for assignment in this study because it permits the calculation of exclusion (i.e. rejection of unknown individuals from baseline samples at different significance levels), which is important in a forensic application.
To estimate the extent of rejection, myocardial biopsy samples were graded for lymphocytic infiltration and necrotic changes as described [9].
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