Sentence examples for rejection clearance from inspiring English sources
In the past, we applied inductive reasoning [ 1] to identify immunologic signatures associated with tumor rejection, clearance of pathogen, acute allograft rejection or autoimmunity.
Thus, although the mechanisms originating acute allograft rejection, clearance of pathogens during acute infection, flares of autoimmunity or cancer regression may be different, in the end, they all converge into a cascade of immunologic steps capable of turning a chronic and lingering inflammatory process into an acute and destructive one.
These genes have been described as highly associated with TSD in the context of acute allograft rejection, pathogen clearance during acute infection and tumor rejection during immunotherapy [ 2].
Treatment with an agonistic anti-CD137 antibody (clone 2A) in mice can cause CD8+ T cell-dependent tumor rejection and virus clearance [5], [6].
These signatures precisely reproduce those observed in humans during immune-mediated tissue-specific destruction (TSD) that causes tumor or allograft rejection, autoimmunity or clearance of pathogens.
This improvement is significant, as an anti-transgene immune response could prompt the clearance and rejection of the genetically modified cells [87].
An early rejection led the group to seek clearance from regulators in Europe and America for a formal bid.
Previous studies underscore the pivotal role of ICAM-1 in the rejection of immunogenic tumors but not for clearance of systemic infections, suggesting their particular role in anti-tumor immunity.
There remains a paucity of data relating to particular immunosuppressive regimes and appropriate dosing schedules, which allow for optimal viral clearance with maintenance of anti-rejection effect.
Such glycan residues are not present in humans, and thus proteins could cause immune rejection inducing plant-glycan specific antibodies causing protein clearance in blood stream as well as potential allergenic effects [ 54– 54].
