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At the first trial of reinstatement test after being reinstated with shock, PIT had significantly higher shock US expectancy than PVT.
Paradoxically, WKY rats demonstrated a latent sensitization to the conditioned rewarding effects of cocaine during the drug-primed reinstatement test.
To measure persistence, rats were subject to a reinstatement test using 3 mg/kg dose of morphine.
Additionally, the 0.3 and 1.0 doses of varenicline non-specifically increased active lever responding during the reinstatement test sessions.
Preference scores for SD rats during the cocaine primed reinstatement test were significantly different from pretest scores indicating reinstatement of CPP in this group.
We used two different designs: 1) a between-subjects design with a unique reinstatement test; and 2) a counterbalanced within-subjects design, with 4 reinstatement tests.
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All rats again received all doses of varenicline over 4 separate reinstatement tests performed on 4 consecutive days.
There was no evidence that variations in fearfulness or sociality (measured in tonic immobility and social reinstatement tests) affected the outcome of the cognitive bias tests.
Extinction was followed by meth-primed (0.3 mg/kg IP) reinstatement tests to examine the effect of varenicline on meth-seeking behavior.
Following seven days of extinction sessions in which neither cues nor drug were available, rats underwent four reinstatement tests in a counterbalanced, within-subjects design.
To do this, we used TTX administration to functionally inactivate the PVT prior to cocaine-primed reinstatement testing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com