Sentence examples for reinstatement model from inspiring English sources

These models include the reinstatement model, the alcohol deprivation model and the point-of-no-return model.

Further, it is important that the site(s) at which CART exerts its inhibitory effects in a reinstatement model be determined.

One example is the reinstatement model of drug-seeking which is proposed to be a model of craving and relapse [6], [10], [11], [12].

The reinstatement model has also shown predictive validity as drugs which are currently prescribed for relapse prevention decrease drug-seeking in rodents [14], [15], [16].

Using a reinstatement model, in conjunction with inactivation of different pathways involved in drug addiction, the neural circuitry involved in reinstatement of drug-seeking has been mapped (Kalivas and McFarland, 2003).

One key difference between animal reinstatement models and human relapse, however, is that a relapsing animal will not actually obtain any alcohol because responding on the previously drug-paired lever during reinstatement testing does not result in the delivery of alcohol (nor does the expression of a place preference result in alcohol administration).

Based on findings from multiple experiments using the extinction-reinstatement model, a 'final common pathway' for drug-seeking has been proposed, as that projecting from the medial prefrontal cortex (mPFC) to the nucleus accumbens core [43].

An important characteristic of D3R antagonism is that it is not associated with debilitating motor or other extra-pyramidal side effects that probably prevent the use of DA D1 or D2 receptor antagonists clinically to prevent relapse, even though they prevent reinstatement in animal models.

In conclusion, our findings suggest that the present reinstatement procedure for mouse model of relapse is useful and reliable, and different neural mechanisms may be involved in drug-primed and cue-induced METH-seeking behavior.

In general, the results partially support the valence-arousal model of reinstatement.

The valence-arousal model of reinstatement raises the possibility that strategies designed to decrease post-extinction negative valence of the CS+ may reduce the effects of reinstatement.