In the three control groups (where either reactivation, stress, or both components were missing) reinstatement effects were seen as expected.
We predict that positive mood induction may reduce reinstatement effects by decreasing negative valence towards the CS+.
The hypothesis that PIT would decrease reinstatement effects compared to PVT was analyzed using Training Group (PIT, PVT) × Reinstatement US Type (Shock, Scream) × CS (CS+, CS−) × Time (Last Trial of Extinction Retest, First Trial of Reinstatement Test) mixed models with SR, shock US expectancy, and self-report fear as the dependent variables.
For the Training Group × Time interaction, there was a significant decrease in self-report fear for PIT from post-extinction retest to post-reinstatement; no such effect was observed for PVT.
Three weeks after this relapse, he restarted topiramate on his own, and stated a reinstatement of the therapeutic effect within 10 days.
For PVT who was reinstated with the scream, SR to the CS− significantly increased from the last trial of extinction retest to the first trial of reinstatement test; no such effect was observed for PIT.
For PVT who was reinstated with shock, SR to the CS+ significantly increased from the last trial of extinction retest to the first trial of reinstatement test; no such effect was observed for PIT.
While a procedure involving both imagery and positive information was more effective than its verbal counterpart, we cannot conclude whether the effects on CS+ valence and reinstatement were the result of changes in positive affect, the type of mentation technique used (i.e., imagery, verbal), or the combination of both.
That year Pope Honorius IV effected Giles' reinstatement at the University of Paris, where he taught theology until 1291.
The current study addresses new ways to mitigate the effects of reinstatement.
