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Are these Tregitopes serving an important purpose, reinforcing tolerance to proteins that are critically important for human survival?
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We need to promote and reinforce tolerance.... Then he makes sounds that optimists will highlight: We should not just tolerate others.
During evolution, modulating gene expression and increasing gene numbers possibly allows the different PHO1genes to act synergistically to promote plant development and to reinforce tolerance to environment stresses.
While GVAX monotherapy has shown moderate clinical efficacy, this may be improved upon through interference with checkpoints at the T-cell level that under normal circumstances serve to reinforce tolerance but that in tumor-conditioned environments may suppress appropriate anti-tumor immune responses.
It also said that it had found two instances of employees being disciplined by being forced to stand at attention, and that it had initiated a manager and employee training program to reinforce a "zero tolerance" policy toward harsh treatment.
"As we look to our reopening this weekend we are implementing a number of measures to protect the safety of our customers and reinforce our zero tolerance policy to drugs.
These expectations are outlined in GM's standard purchase contract terms and conditions, which reinforce our zero-tolerance policy against the use of child labour, abusive treatment of employees or corrupt business practices in the supply of goods and services to GM.
These findings reinforce implementing zero-tolerance policies toward bullying in schools and provide a strong argument that prevention of bullying should start as early as possible.
For example, both increases and decreases in the reinforcing efficacy of cocaine have observed following paradigms that produce tolerance to cocaine effects at the DAT.
It is known that reinforcing with additional material at the cutout zones can extend the damage tolerance of a structure, therefore maintaining structural integrity and load carrying capacity.
By reinforcing our understanding of the basic cellular and molecular mechanisms of immune tolerance, we could develop more effective therapy for the patients who need transplantation.
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