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The report lists five core "pillars" which underpin the its various "interconnected and mutually reinforcing responses" — all of which are in turn aimed at forming a holistic overarching strategy to attack the problem from multiple angles and time-scales.
In the latter case, the notion that the inflammatory and senescent phenotypes may be mutually reinforcing responses that are capable of inducing pathological changes in a paracrine fashion establishes a new framework for understanding the interplay between chronic neuroinflammation and neuronal dysfunction.
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The PCB-exposed monkeys discussed above also displayed increased response rates and a concomitant decrease in the number of reinforced responses on a differential reinforcement of low rate (DRL) schedule, which punishes failure to inhibit inappropriate responding (Rice 1998).
The ability to inhibit reinforced responses is widely studied using the Differential Reinforcement of Low rates (DRL) preparation in both humans [ 8- 13] and animals [ 14- 18].
We tested 167 children on a DRL20 (20 sec) reinforcement schedule, and recorded IRTs and the number of reinforced responses across the session.
Toxic ideologies express and reinforce responses to social conflict that are generically human.
Response inhibition capacity (RIC), the ability to withhold instrumentally reinforced responses, is compromised in ADHD.
The inability to inhibit reinforced responses is a defining feature of ADHD associated with impulsivity.
However, monkeys with higher BLLs (33 μg/dL) had fewer reinforced responses and shorter average interresponse times.
Further, all three contaminants PCBs, Pb, and MeHg were associated with a reduced percentage of reinforced responses.
The elevated rate of weakly reinforced responses is the signature of operant hyperactivity in SHR [ 32, 33].
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