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Our findings reinforce sequence errors that have been reported elsewhere for pRS416 and pRS426 (Tomlin et al. 2001) as well as the HIS3 -marked pRS vectors (http://genome-www.stanford.edu/vectordb/vector.html).html
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Red lines correspond to mean values for reinforced sequences.
The percentage of reinforced sequences tended to decrease, since the difficulty of the task increased across sessions, but tended to stabilize or increase when the same target difficulty was repeated in two consecutive sessions (F8,152 = 57.31, p < 0.0001; Figure 1 figure supplement 1B).
Methods such as CHASE incorporate some of the above methods in a combined manner to reinforce the sequence search.
Recent advances in next generation sequencing reinforce the potential for DNA sequence markers to guide esophageal cancer management.
(C, D ) Variance and (E, F ) variability, measured as the Fano factor, for reinforced and non-reinforced sequences.
We would like to first clarify that variability in number of presses or sequence duration was not different between reinforced and non-reinforced sequences (see Figure 3).
To further investigate this, we analyzed if the variability of these two behavioral dimensions was different in reinforced vs non-reinforced sequences.
Reinforced sequences had lower variability in frequency than non-reinforced sequences, but had equal variability in duration as non-reinforced sequences.
Finally, tasks were often introduced in a stepwise manner, progressing from the easiest to the most difficult conditions, which might have had the effect of training the subjects by reinforcing simple sequences of behaviour generated through random processes [8], [12], [13], [27].
Dopamine cells could coordinate with and reinforce replayed hippocampal sequences.
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