This pattern documents that social learning through peer-to-peer information exchange can serve as a complementary and reinforcing pathway with technical learning that is stimulated by traditional outreach and extension programs.
In the context of a neurodegenerative cascade we would propose that senescence of CNS cells is a reinforcing pathway downstream of a proteinopathy that can, in an autocrine and paracrine fashion, create an environment that results in aging of the brain.
In this review, I summarize and integrate these findings with a particular focus on the redundant yet mutually reinforcing pathways that enable long-term transcriptional repression throughout the soma.
The findings of this study invite the possibility that mental health and empowerment are closely aligned concepts, and that their realisation potentially has shared and mutually reinforcing pathways.
Similarly, genome-wide expression profiling studies have revealed candidate genes that reinforce consensus pathways but also demonstrate tissue-specificity [1], [13], [16], which likely has implications for aging-associated diseases of specific tissues.
38 57–59 When the motor cortex is damaged (eg, congenital brain lesion), action observation and imitation may influence cortical reorganisation by directly restoring the damaged motor pathways or reinforcing other pathways that originally helped to perform motor actions, or both.
Therefore, HIPK2 not only activates the p53-apoptotic pathway by direct phosphorylation but it also reinforces this pathway by phosphorylating Che-1 and inducing its degradation.
Thirdly, both BCL9 and B9L are Wnt-inducible genes that are hyperexpressed in colorectal cancer cell lines, indicating that they are part of a positive feedback loop, reinforcing Wnt pathway activity.
In addition, considering that both Lin28B and MCPIP1 can be induced by inflammatory signals along with activation of NF-κB pathway, 37, 39 coordinated regulation of MCPIP1 and Lin28B may reinforce the uridylation pathway to effectively block the biogenesis of let-7.
The Research Assistant and Chief Investigator will facilitate education sessions during implementation to review evidence underpinning the clinical pathway and reinforce the role of the pathway itself.
