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The compound binds at the AMP regulatory site by X-ray crystallography.
A hypothetical sodium leak is added to the scheme as the sole regulatory site.
The enrichment of mutations suggests that the candidate ATP-binding motifs contain key regulatory site(s) for the channel function, providing a validation of our reasoning.
They are at the heart of a diverse range of programs, including genefinding, profile searches, multiple sequence alignment and regulatory site identification.
In the rat enzyme these phosphorylation sites correspond to Ser563 (regulatory site) and Ser565 (basal site).
Thus, exposure to DNA damage induces dephosphorylation of Net1 on its negative regulatory site.
The pulmonary microcirculation is the chief regulatory site for resistance in the pulmonary circuit.
This speculation is supported by a recent report that demonstrates PP2-mediated increase in phosphorylation at the positive regulatory site Tyr-416 in Src and decrease in phosphorylation at the negative regulatory site Tyr-529 [31].
The findings not only specified the requirement of extra regulatory site, it also identified when such regulation is occurring.
Decreased phosphorylation of Net1 on the key negative regulatory site Ser152 was used as the hallmark of Net1 activation [15].
One site was phosphorylated under basal conditions (the basal site) and another was phosphorylated by protein kinase A (PKA) upon stimulation of lipolysis (the regulatory site).
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CEO of Professional Science Editing for Scientists @ prosciediting.com